Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic.

ABSTRACT: An increased understanding of the complex mechanisms at play within the tumor microenvironment (TME) has emphasized the need for the development of strategies that target immune cells within the TME. Therapeutics that render the TME immune-reactive have a vast potential for establishing effective cancer interventions. One such intervention is β-glucan, a natural compound with immune-stimulatory and immunomodulatory potential that has long been considered an important anti-cancer therapeutic. β-glucan has the ability to modulate the TME both by bridging the innate and adaptive arms of the immune system and by modulating the phenotype of immune-suppressive cells to be immune-stimulatory. New roles for β-glucan in cancer therapy are also emerging through an evolving understanding that β-gluca

SUBMITTER: Geller A 

PROVIDER: S-EPMC6695648 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature