GARP as an Immune Regulatory Molecule in the Tumor Microenvironment of Glioblastoma Multiforme.

ABSTRACT: Glycoprotein A repetition predominant (GARP), a specific surface molecule of activated regulatory T cells, has been demonstrated to significantly contribute to tolerance in humans by induction of peripheral Treg and regulatory M2-macrophages and by inhibition of (tumorantigen-specific) T effector cells. Previous work identified GARP on Treg, and also GARP on the surface of several malignant tumors, as well as in a soluble form being shedded from their surface, contributing to tumor immune escape. Preliminary results also showed GARP expression on brain metastases of malignant melanoma. On the basis of these findings, we investigated whether GARP is also expressed on primary brain tumors. We showed GARP expression on glioblastoma (GB) cell lines and primary GB tissue, as well as on low-grad

SUBMITTER: Zimmer N 

PROVIDER: S-EPMC6695992 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature