Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046.

ABSTRACT: A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC₅₀ values ranging from 0.5 to 7.7 μM. Compounds 1 and 2

SUBMITTER: Li J 

PROVIDER: S-EPMC6696147 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature