Prediction of Transformation Products of Monensin by Electrochemistry Compared to Microsomal Assay and Hydrolysis.

ABSTRACT: The knowledge of transformation pathways and identification of transformation products (TPs) of veterinary drugs is important for animal health, food, and environmental matters. The active agent Monensin (MON) belongs to the ionophore antibiotics and is widely used as a veterinary drug against coccidiosis in broiler farming. However, no electrochemically (EC) generated TPs of MON have been described so far. In this study, the online coupling of EC and mass spectrometry (MS) was used for the generation of oxidative TPs. EC-conditions were optimized with respect to working electrode material, solvent, modifier, and potential polarity. Subsequent LC/HRMS (liquid chromatography/high resolution mass spectrometry) and MS/MS experiments were performed to identify the structures of derived TPs by

SUBMITTER: Kotthoff L 

PROVIDER: S-EPMC6696283 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature