The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration.

ABSTRACT:

Background

Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD.

Results

We sampled fresh venous blood from patients with geographic atrophy (GA) secondary to AMD without choroidal neovascularizations (n = 19), patients with neovascular AMD without GA (n = 38), patients with polypoidal choroidal vasculopathy (PCV) (n = 19), and aged control individuals with healthy retinae (n = 20). We isolated PBMCs, extracted RNA, and used microarray to investigate gene expression. Volcano plots identified statistically significant differentially expressed genes (P < 0.05) at a

SUBMITTER: Subhi Y 

PROVIDER: S-EPMC6696679 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature