Whole-Exome Sequencing of an Exceptional Longevity Cohort.

ABSTRACT: Centenarians represent a unique cohort to study the genetic basis for longevity and factors determining the risk of neurodegenerative disorders, including Alzheimer's disease (AD). The estimated genetic contribution to longevity is highest in centenarians and super-cententenarians, but few genetic variants have been shown to clearly impact this phenotype. While the genetic risk for AD and other dementias is now well understood, the frequency of known dementia risk variants in centenarians is not fully characterized. To address these questions, we performed whole-exome sequencing on 100 individuals of 98-108 years age in search of genes with large effect sizes towards the exceptional aging phenotype. Overall, we were unable to identify a rare protein-altering variant or individual genes wit

SUBMITTER: Nygaard HB 

PROVIDER: S-EPMC6696723 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature