Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study.

ABSTRACT:

Background

While the genetic contribution to obesity is well established, few studies have examined how genetic variants influence standardized body mass index Z-score (BMIz) in Hispanics/Latinos, especially across childhood and adolescence.

Objectives

We estimated the effect of established BMIz loci in Chilean children of the Santiago Longitudinal Study (SLS).

Methods

We examined associations with BMIz at age 10 for 15 loci previously identified in European children. For significant loci, we performed association analyses at ages 5 and 16 years, for which we have smaller sample sizes. We tested associations of unweighted genetic risk scores (GRSs) for previously identified tag variants (GRS_EUR) and from the most significant variants in SLS at each locus (GRS_SLS).

SUBMITTER: Justice AE 

PROVIDER: S-EPMC6696926 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature