Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis.

ABSTRACT:

Background & aims

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver transplantation, and many trials are underway to evaluate potential therapies. The farnesoid X receptor ligand obeticholic acid in the NASH treatment trial evaluated the effects of obeticholic acid vs placebo on histologic response (defined as decrease in nonalcoholic fatty liver disease activity score [NAS] by ≥2, with no worsening of fibrosis); 45% of patients had a histologic response to obeticholic acid (25 mg), and 21% had a response to placebo (P < .01). We performed a secondary analysis of data from this trial to identify clinical parameters associated with a histologic response.

Methods

We used a logistic regression model with a stepwise selection procedure to identify baseline and earl

SUBMITTER: Loomba R 

PROVIDER: S-EPMC6696948 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature