Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy.

ABSTRACT: Diabetic retinopathy remains the major cause of blindness among working age adults. Although a number of metabolic abnormalities have been associated with its development, due to complex nature of this multi-factorial disease, a link between any specific abnormality and diabetic retinopathy remains largely speculative. Diabetes increases oxidative stress in the retina and its capillary cells, and overwhelming evidence suggests a bidirectional relationship between oxidative stress and other major metabolic abnormalities implicated in the development of diabetic retinopathy. Due to increased production of cytosolic reactive oxygen species, mitochondrial membranes are damaged and their membrane potentials are impaired, and complex III of the electron transport system is compromised. Suboptima

SUBMITTER: Kowluru RA 

PROVIDER: S-EPMC6697077 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature