Molecular markers for corneal epithelial cells in larval vs. adult Xenopus frogs.

ABSTRACT: Corneal Epithelial Stem Cells (CESCs) and their proliferative progeny, the Transit Amplifying Cells (TACs), are responsible for maintaining the integrity and transparency of the cornea. These stem cells (SCs) are widely used in corneal transplants and ocular surface reconstruction. Molecular markers are essential to identify, isolate and enrich for these cells, yet no definitive CESC marker has been established. An extensive literature survey shows variability in the expression of putative CESC markers among vertebrates; being attributed to species-specific variations, or other differences in developmental stages of these animals, approaches used in these studies and marker specificity. Here, we expanded the search for CESC markers using the amphibian model Xenopus laevis. In previous stud

SUBMITTER: Sonam S 

PROVIDER: S-EPMC6697113 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature