Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use.

ABSTRACT: Theoretical and empirical work suggests that problematic substance use (PSU) is associated with individual differences in prefrontal cortex activity. While research has strongly linked parietal P3 amplitude reduction (P3AR) to genetic risk for problematic substance use, few studies have tested whether prefrontal EEG measures are sensitive to this genetic liability. In addition to P3, oddball target detection tasks elicit medial frontal theta power, reflecting attentional allocation, and parietal delta, indexing decision making or stimulus-response link updating. Midfrontal theta and parietal delta may index neurocognitive processes relevant to PSU beyond P3AR. The present investigation examined the etiological relationship between PSU and P3, frontal theta, and parietal delta in a large tw

SUBMITTER: Harper J 

PROVIDER: S-EPMC6697141 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature