Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors.

ABSTRACT: Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhancement (ADE). A panel of mAbs obtained from human survivors of filovirus infection caused by Ebola, Bundibugyo, or Marburg viruses was evaluated for their ability to facilitate ADE. ADE was observed readily with all mAbs examined at sub-neutralizing concentrations, and this effect was not restricted to mAbs with a particular epitope specificity, neutralizing capacity, or subclass. Blocking of specific Fcγ receptors reduced but did not abolish ADE that was associated with high-affinity binding antibodies, suggesting that lower-affinity interactions still c

SUBMITTER: Kuzmina NA 

PROVIDER: S-EPMC6697154 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature