High-Frequency Stimulation on Skeletal Muscle Maintenance in Female Cachectic Mice.

ABSTRACT: Cancer cachexia, an unintentional body weight loss due to cancer, affects patients' survival, quality of life, and response to chemotherapy. Although exercise training is a promising intervention to prevent and treat cancer cachexia, our mechanistic understanding of cachexia's effect on contraction-induced muscle adaptation has been limited to the examination of male mice. Because sex can affect muscle regeneration and response to contraction in humans and mice, the effect of cachexia on the female response to eccentric contraction warrants further investigation.

Purpose

The purpose of this study was to determine whether high-frequency electric stimulation (HFES) could attenuate muscle mass loss during the progression of cancer cachexia in female tumor-bearing mice.

Methods

F

SUBMITTER: Sato S 

PROVIDER: S-EPMC6697199 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature