CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.

ABSTRACT: Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-phagocytic surface proteins called 'don't eat me' signals-including CD47¹, programmed cell death ligand 1 (PD-L1)² and the beta-2 microglobulin subunit of the major histocompatibility class I complex (B2M)³. Monoclonal antibodies that antagonize the interaction of 'don't eat me' signals with their macrophage-expressed receptors have demonstrated therapeutic potential in several cancers^4,5. However, variability in the magnitude and durability of the response to these agents has suggested the prese

SUBMITTER: Barkal AA 

PROVIDER: S-EPMC6697206 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature