Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells.

ABSTRACT: The growth plate provides a substantial source of mesenchymal cells in the endosteal marrow space during endochondral ossification. The current model postulates that a group of chondrocytes in the hypertrophic zone can escape from apoptosis and transform into cells that eventually become osteoblasts in an area beneath the growth plate. The growth plate is composed of cells with various morphologies; particularly at the periphery of the growth plate immediately adjacent to the perichondrium are "borderline" chondrocytes, which align perpendicularly to other chondrocytes. However, in vivo cell fates of these special chondrocytes have not been revealed. Here we show that borderline chondrocytes in growth plates behave as transient mesenchymal precursor cells for osteoblasts and marrow stromal

SUBMITTER: Mizuhashi K 

PROVIDER: S-EPMC6697228 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature