The Cancer Immunogram as a Framework for Personalized Immunotherapy in Urothelial Cancer.

ABSTRACT:

Context

The abysmal outlook of urothelial cancer (UC) has changed with the introduction of immunotherapy. Still, many patients do not respond and distinctive biomarkers are currently lacking. The rise of this novel armamentarium of immunotherapy treatments, in combination with the complex biology of an immunological tumor response, warrants the development of a comprehensive framework that can provide an overview of important immunological processes at play in individual patients.

Objective

To develop a comprehensive framework based on tumor- and host-specific parameters to understand immunotherapy response in UC. This framework can inform rational, biology-driven clinical trials and ultimately guide us toward individualized patient treatment.

Evidence acquisition

A l

SUBMITTER: van Dijk N 

PROVIDER: S-EPMC6697269 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature