Beyond sequence homology: Cellular biology limits the potential of XIST to act as a miRNA sponge.

ABSTRACT:

Introduction

The sponging of microRNAs by a long non-coding RNA (lncRNA) away from their coding gene targets is a conceptually-simple, yet biologically-complex method of lncRNA-mediated gene regulation. Currently, predictions of genes that participate in sponge-based regulation are largely based on sequence homology alone, which may not adequately reflect the cellular environment in which lncRNA:miRNA pairs interact. The vast number of potential interactions generated by these predictions impedes the identification of functional gene regulatory relationships, which necessitates an approach that considers biological context. XIST, the female-specific lncRNA canonically involved in silencing the X chromosome, has been suggested by many studies to act as a miRNA sponge. The sex-specif

SUBMITTER: Marshall EA 

PROVIDER: S-EPMC6697314 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature