Sustained Oscillations of Epithelial Cell Sheets.

ABSTRACT: Morphological changes during development, tissue repair, and disease largely rely on coordinated cell movements and are controlled by the tissue environment. Epithelial cell sheets are often subjected to large-scale deformation during tissue formation. The active mechanical environment in which epithelial cells operate have the ability to promote collective oscillations, but how these cellular movements are generated and relate to collective migration remains unclear. Here, combining in vitro experiments and computational modeling, we describe a form of collective oscillations in confined epithelial tissues in which the oscillatory motion is the dominant contribution to the cellular movements. We show that epithelial cells exhibit large-scale coherent oscillations when constrained within m

SUBMITTER: Peyret G 

PROVIDER: S-EPMC6697349 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature