Salicylate Increases Fitness Cost Associated with MarA-Mediated Antibiotic Resistance.

ABSTRACT: Antibiotic resistance is generally associated with a fitness deficit resulting from the burden of producing and maintaining resistance machinery. This additional cost suggests that resistant bacteria will be outcompeted by susceptible bacteria in conditions without antibiotics. However, in practice, this process is slow in part because of regulation that minimizes expression of these genes in the absence of antibiotics. This suggests that if it were possible to turn on their expression, the cost would increase, thereby accelerating removal of resistant strains. Experimental and theoretical studies have shown that environmental chemicals can change the fitness cost associated with resistance and therefore have a significant impact on population dynamics. The multiple antibiotic resistance a

SUBMITTER: Wang T 

PROVIDER: S-EPMC6697527 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature