Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme.

ABSTRACT: Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca²⁺ and K⁺ homeostasis and by affecting the organization of the mitotic spindles. However, to preserve healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. In this work, we propose a nanotechnological approach based on ultrasound-sensitive piezoelectric nanoparticles to remotely deli

SUBMITTER: Marino A 

PROVIDER: S-EPMC6697537 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature