Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy.

ABSTRACT:

Background

Hippocampal enlargements are commonly reported after electroconvulsive therapy (ECT). To clarify mechanisms, we examined if ECT-induced hippocampal volume change relates to dose (number of ECT sessions and electrode placement) and acts as a biomarker of clinical outcome.

Methods

Longitudinal neuroimaging and clinical data from 10 independent sites participating in the Global ECT-Magnetic Resonance Imaging Research Collaboration (GEMRIC) were obtained for mega-analysis. Hippocampal volumes were extracted from structural magnetic resonance images, acquired before and after patients (n = 281) experiencing a major depressive episode completed an ECT treatment series using right unilateral and bilateral stimulation. Untreated nondepressed control subjects (n = 95) were

SUBMITTER: Oltedal L 

PROVIDER: S-EPMC6697556 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature