The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats.

ABSTRACT:

Rationale

Mitragyna speciosa (kratom) may hold promise as both an analgesic and treatment for opioid use disorder. Mitragynine, its primary alkaloid constituent, is an opioid receptor ligand. However, the extent to which the in vivo effects of mitragynine are mediated by opioid receptors, or whether mitragynine interacts with other opioid agonists, is not fully established.

Objectives

The effects of mitragynine and the prototypical opioid agonist morphine were compared for their capacity to decrease operant responding for food delivery, and to increase response latency to a thermal stimulus.

Methods

Male and female Sprague-Dawley rats responded under a multiple cycle fixed ratio 10 schedule of food delivery and were tested on a hot plate (52 °C) immediately after each

SUBMITTER: Hiranita T 

PROVIDER: S-EPMC6697625 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature