PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain.

ABSTRACT: Gene transcription is a highly complex and strictly regulated process. RNA polymerase II (Pol II) C-terminal domain (CTD) undergoes massive cycles of phosphorylation and dephosphorylation during the process of gene transcription. These post-translational modifications of CTD provide an interactive platform for various factors required for transcription initiation, elongation, termination, and co-transcriptional RNA processing. Pol II CTD kinases and phosphatases are key regulators and any deviation may cause genome-wide transcriptional dysregulation leading to various pathological conditions including cancer. PTEN, a well known tumor suppressor, is one of the most commonly somatically altered in diverse malignancies. When mutated in the germline, PTEN causes cancer predisposition. N

SUBMITTER: Abbas A 

PROVIDER: S-EPMC6697640 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature