Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma.

ABSTRACT: Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. Met interaction with integrins is shown to modulate the downstream signaling to Akt and ERK (extracellular-regulated kinase). In this study, we developed a mechanistically detailed systems biology model of HGF/Met signaling pathway that incorporated specific interactions with integrins to investigate the efficacy of integrin-binding peptide, AXT050, as monotherapy and in combination with other therapeutics targeting this pathway. Here we report that the modeled dynamics of the response to AXT050 revealed that receptor trafficking is sufficient to explain the effect of Met-integrin interactions on HGF signaling. Furthermore, the model predicted pat

SUBMITTER: Jafarnejad M 

PROVIDER: S-EPMC6697704 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature