Leptin signaling impairs macrophage defenses against Salmonella Typhimurium.

ABSTRACT: The dynamic interplay between metabolism and immune responses in health and disease, by which different immune cells impact on metabolic processes, are being increasingly appreciated. However, the potential of master regulators of metabolism to control innate immunity are less understood. Here, we studied the cross-talk between leptin signaling and macrophage function in the context of bacterial infections. We found that upon infection with Gram-negative pathogens, such as Salmonella Typhimurium, leptin receptor (Lepr) expression increased in both mouse and human macrophages. Unexpectedly, both genetic Lepr ablation in macrophages and global pharmacologic leptin antagonization augmented lysosomal functions, reduced S Typhimurium burden, and diminished inflammation in v

SUBMITTER: Fischer J 

PROVIDER: S-EPMC6697794 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature