Non-concealed placebo treatment for menopausal hot flushes: Study protocol of a randomized-controlled trial.

ABSTRACT:

Background

Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement.

Objective

To determine whether open label placebo (OLP) treatment is efficacious in alleviating hot flushes among peri- and postmenopausal women.

Methods/design

In this assessor-blinded, randomized-controlled trial, n = 100 women experiencing five or more daily hot flushes of at least moderate severity and bothersomeness are assigned 1:1 to a 4-week OLP treatment or no treatment. To explore the duration and maintenance of placebo effects, the OLP group is randomized a second time to either discontinue or continue the OLP treatment for another 4 weeks. All participants receive a brie

SUBMITTER: Pan Y 

PROVIDER: S-EPMC6697911 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature