Cardiac function assessed by myocardial deformation in adult polycystic kidney disease patients.

ABSTRACT:

Background

Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of cardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sign of subclinical cardiac dysfunction even in patients with otherwise preserved ejection fraction (EF). Transmitral early filling velocity to early diastolic strain rate (E/SRe) is a novel measure of LV filling pressure, which is often affected early in cardiac disease.

Methods

A total of 110 ADPKD patients not on dialysis were included in this prospective study. All patients underwent an extensive echocardiographic examination including two-dimensional speckle tracking. GLS and strain rates were measured. The distribution of GLS and E/SRe was determined and p

SUBMITTER: Lassen MCH 

PROVIDER: S-EPMC6697983 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature