CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status.

ABSTRACT:

Background

Triple Negative Breast cancer (TNBC) is incurable cancer with higher rates of relapse and shorter overall survival compared with other subtypes of breast cancer. Cellular retinoic acid binding protein 2 (CRABP2) belongs to fatty acid binding protein (FABP) family which binds with all-trans retinoic acid (RA). Previous studies from the database have reported the patients with high expression of CRABP2 showed different prognosis in ER⁺ and ER^- breast cancer. However, its biological role and exact mechanism in breast cancer remain unknown. This aim of this study was to explore how CRABP2 regulated invasion and metastasis based on the estrogen receptor-α (herein called ER) status in breast cancer.

Methods

Immunohistochemical staining method was u

SUBMITTER: Feng X 

PROVIDER: S-EPMC6697986 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature