Cytokines are associated with longitudinal changes in cognitive performance among urban adults.

ABSTRACT:

Background

Chronic systemic inflammation has been positively associated with structural and functional brain changes representing early markers of Alzheimer's Disease (AD) and cognitive decline. The current study examined associations between systemic inflammation and cognitive performance among African-Americans and Whites urban adults.

Methods

Participants were selected from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (2004-2013, baseline age: 30-64 y, mean ± SD follow-up time of 4.64 ± 0.93 y, N = 189-222, k = 1.5-1.7 observations/participant). Cytokines known to be positively linked to AD incidence among others were tested against cross-sectional and longitudinal cognitive function, stratifying by age group (≤50 y vs. >50 y), sex a

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC6698146 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature