Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.

ABSTRACT: Radiation-induced fibrosis (RIF) is a common delayed effect of acute ionizing radiation exposure (DEARE) affecting diverse tissues including the heart, lungs, liver and skin, leading to reduced tissue function and increased morbidity. Monocytes, which may be classified into classical (CD14⁺⁺, CD16^-), intermediate (CD14⁺⁺, CD16⁺) and non-classical (CD14^+/low, CD16⁺⁺) subtypes in humans and non-human primates (NHPs), and monocyte-derived macrophages may play an integral role in the pathogenesis of RIF. We tested the hypothesis that moderate to high levels of total-body exposure to radiation would alter monocyte polarization and produce phenotypes that could promote multi-organ fibrosis in a wellestablished NHP model of DEARE.

SUBMITTER: Michalson KT 

PROVIDER: S-EPMC6698159 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature