Cortical morphometry in anorexia nervosa: An out-of-sample replication study.

ABSTRACT:

Background

Acute anorexia nervosa (AN) is frequently accompanied by reduced global cortical volume. Investigations of local cortical alterations in AN have revealed widespread reduction in cortical thickness, gyrification, and curvature. The aim of the present study was to combine data from two previous studies to replicate previous findings.

Methodology

Magnetic resonance imaging (MRI) images from 46 adult women with AN and 54 age-matched healthy comparison (HC) women were analysed using FreeSurfer. Group differences in cortical volume and local cortical measures, including gyrification, curvature, thickness, and area, were examined controlling for dataset and age.

Results

The AN group had reduced global cortical volume relative to the HC group. The AN group also had

SUBMITTER: Leppanen J 

PROVIDER: S-EPMC6698193 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature