Kidney Tubular Damage and Functional Biomarkers in Acute Kidney Injury Following Cardiac Surgery.

ABSTRACT:

Background

Cardiac surgery-associated acute kidney injury (AKI) is associated with increased morbidity and mortality. We examined the utility of combining biomarkers of kidney function loss (serum cystatin C) and kidney tubular damage (urine neutrophil gelatinase-associated lipocalin [NGAL] and Kidney Injury Molecule-1 [KIM-1]) for the prediction of post-cardiac surgery AKI.

Methods

Single-center prospective cohort study of 106 adults undergoing coronary artery bypass grafting and/or valve surgery with cardiopulmonary bypass (CPB). Primary outcome was postoperative in-hospital AKI defined by serum creatinine (SCr)-Kidney Disease: Improving Global Outcomes criteria. Biomarkers were measured preoperatively, 6 hours after CPB and on postoperative days (PODs) 1 to 4.

Results<

SUBMITTER: Neyra JA 

PROVIDER: S-EPMC6698294 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature