A Systematic Review and Meta-analysis of Nonpharmacologic-based Interventions for Aortic Stiffness in End-Stage Renal Disease.

ABSTRACT:

Introduction

Increased carotid-femoral pulse wave velocity (cf-PWV) in end-stage renal disease (ESRD) indicates enhanced aortic stiffness and mortality risk. We conducted a systematic review and meta-analysis of nonpharmacologic interventions in adults with ESRD to determine their effects on cf-PWV, systolic blood pressure (SBP), and intervention-associated adverse events.

Methods

MEDLINE, EMBASE, and EBM databases were searched. Study screening, selection, data collection, and methodological quality assessments were performed by 2 independent reviewers. Pooled-effect estimates from mean differences and 95% confidence intervals (CIs) were calculated using random effect models.

Results

A total of 2166 subjects with ESRD from 33 studies (17 randomized; 16 nonrandomized)

SUBMITTER: Rodriguez RA 

PROVIDER: S-EPMC6698308 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature