Following of aging process in a new motor skill learning model, "pot jumping" in rats.

ABSTRACT: Impairment of procedural memory is a frequent and severe symptom in many neurological and psychiatric diseases as well as during aging. Our aim was to establish an assay in rats in which procedural learning and changes in performance can be studied on the long term. The work was done in the frame of a larger project aiming to establish a complex cognitive animal test battery of high translational value. The equipment was a 190-cm-diameter circular water tank where 12 flower pots were placed upside down in a circle with increasing distances (18-46 cm) between the adjacent ones. Male Lister Hooded and Long-Evans rats were allowed to move on the pots for 3 min. The arena was filled with shallow water to make the rats stay on the pots. Animals were obviously motivated to move around on the pot

SUBMITTER: Ernyey AJ 

PROVIDER: S-EPMC6698317 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature