Superhydrophobic Photosensitizers: Airborne ¹O₂ Killing of an in Vitro Oral Biofilm at the Plastron Interface.

ABSTRACT: Singlet oxygen is a potent agent for the selective killing of a wide range of harmful cells; however, current delivery methods pose significant obstacles to its widespread use as a treatment agent. Limitations include the need for photosensitizer proximity to tissue because of the short (3.5 μs) lifetime of singlet oxygen in contact with water; the strong optical absorption of the photosensitizer, which limits the penetration depth; and hypoxic environments that restrict the concentration of available oxygen. In this article, we describe a novel superhydrophobic singlet oxygen delivery device for the selective inactivation of bacterial biofilms. The device addresses the current limitations by: immobilizing photosensitizer molecules onto inert silica particles; embedding the photosensitizer

SUBMITTER: Pushalkar S 

PROVIDER: S-EPMC6698391 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature