Noninvasive imaging of the tree shrew eye: Wavefront analysis and retinal imaging with correlative histology.

ABSTRACT: Tree shrews are small mammals with excellent vision and are closely related to primates. They have been used extensively as a model for studying refractive development, myopia, and central visual processing and are becoming an important model for vision research. Their cone dominant retina (∼95% cones) provides a potential avenue to create new damage/disease models of human macular pathology and to monitor progression or treatment response. To continue the development of the tree shrew as an animal model, we provide here the first measurements of higher order aberrations along with adaptive optics scanning light ophthalmoscopy (AOSLO) images of the photoreceptor mosaic in the tree shrew retina. To compare intra-animal in vivo and ex vivo cone density measurements, the AOSLO images were mat

SUBMITTER: Sajdak BS 

PROVIDER: S-EPMC6698412 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature