A novel electro-chemotactic approach to impact the directional migration of transplantable retinal progenitor cells.

ABSTRACT: Photoreceptor degeneration is a significant cause of visual impairment in the United States and globally. Cell replacement therapy shows great promise in restoring vision by transplanting stem-like cells into the sub-retinal space as substitutes for damaged photoreceptors. However, vision repair via transplantation has been limited, in large part, by low numbers of replacement cells able to migrate into damaged retinal tissue and integrate with native photoreceptors. Projects have used external chemical fields and applied electric fields to induce the chemotaxis and electrotaxis of replacement cells, respectively, with limited success. However, the application of combined electro-chemotactic fields in directing cells within biomaterials and host tissue has been surprisingly understudied. T

SUBMITTER: Mishra S 

PROVIDER: S-EPMC6698415 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature