Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy.

ABSTRACT:

Objective

To study the effectiveness and tolerability of antiepileptic drugs (AEDs) commonly used in juvenile myoclonic epilepsy (JME).

Methods

People with JME were identified from a large database of individuals with epilepsy, which includes detailed retrospective information on AED use. We assessed secular changes in AED use and calculated rates of response (12-month seizure freedom) and adverse drug reactions (ADRs) for the five most common AEDs. Retention was modeled with a Cox proportional hazards model. We compared valproate use between males and females.

Results

We included 305 people with 688 AED trials of valproate, lamotrigine, levetiracetam, carbamazepine, and topiramate. Valproate and carbamazepine were most often prescribed as the first AED. The response

SUBMITTER: Silvennoinen K 

PROVIDER: S-EPMC6698679 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature