Olfactory function in focal epilepsies: Understanding mesial temporal lobe epilepsy beyond the hippocampus.

ABSTRACT: Several lines of research have linked olfactory regions with the pathophysiology of focal epilepsies. Among those regions, the piriform cortex represents the major part of the primary olfactory cortex. According to these data, we raised the hypothesis that in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis exists an interictal dysfunction of olfactory processing that could be more significant compared to patients with extra-hippocampal focal epilepsy and healthy controls. This could be the consequence of a dysfunctional epileptogenic network that extends beyond the hippocampus and affects other structures, including the piriform cortex. To test this hypothesis, we evaluated the olfactory function with the Sniffin' Sticks test in 32 patients with mesial tem

SUBMITTER: Espinosa-Jovel C 

PROVIDER: S-EPMC6698687 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature