Changes in drug load during lacosamide combination therapy: A noninterventional, observational study in German and Austrian clinical practice.

ABSTRACT:

Introduction

Effects of antiepileptic drug (AED) load changes in patients with focal seizures have not been well evaluated.

Methods

SP1065 (NCT01673282) was a noninterventional, prospective, observational study conducted in a clinical practice setting. Patients (aged ≥18 years) with focal seizures were enrolled within 7 days of being prescribed adjunctive lacosamide. Observation period was ~6 months. Drug load was assessed using percentage change in ratio of actual prescribed dose and World Health Organization defined daily dose (DDD) for concomitant AEDs and all AEDs (including lacosamide). Subgroups were defined for patients with at least one concomitant sodium channel-blocking AED (SCB [+]) and those without (SCB [-]).

Results

A total of 311 patients were assessed

SUBMITTER: Reinhardt F 

PROVIDER: S-EPMC6698692 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature