The Mechanistic Basis for Successful Spinal Cord Stimulation to Generate Steady Motor Outputs.

ABSTRACT: Electrical stimulation of the spinal cord is a promising rehabilitation intervention to restore/augment motor function after spinal cord injury (SCI). Combining sensory feedback with stimulation of remaining motor circuits has been shown to be a prerequisite for the functional improvement of SCI patients. However, little is known about the cellular mechanisms potentially underlying this functional benefit in the injured spinal cord. Here, we combine computer simulations with an isolated whole-tissue adult mouse spinal cord preparation to examine synaptic, cellular, and system potentials measured from single motoneurons and ventral roots. The stimulation protocol included separate and combined activation of the sensory inputs (evoked by dorsal root stimulation) and motor inputs (evoked by s

SUBMITTER: Mahrous AA 

PROVIDER: S-EPMC6698793 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature