Hepatoprotective effects of silymarin on CCl₄-induced hepatic damage in broiler chickens model.

ABSTRACT: This study was conducted to investigate the hepatoprotective effects of silymarin on CCl₄-induced oxidative stress in broiler chickens model. A total of 240 day-old broilers were divided into 4 equal groups (n = 60) composed of a control group (receiving 1 mL/Kg BW saline) and 3 groups treated with silymarin (receiving 100 mg/Kg BW silymarin), CCl₄ (receiving 1 mL/Kg BW CCl₄), and combination of silymarin + CCl₄. Results indicated that silymarin has potential to mitigate the deleterious effects of CCl₄ on protein and lipid metabolism. The protective activity of silymarin against CCl₄-mediated lipid peroxidation was demonstrated by the lower serum content of MDA, as lipid peroxidation marker. CCl₄-induced hepatotox

SUBMITTER: Baradaran A 

PROVIDER: S-EPMC6698800 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature