Small-Format Drug Conjugates: A Viable Alternative to ADCs for Solid Tumours?

ABSTRACT: Antibody-Drug Conjugates (ADCs) have been through multiple cycles of technological innovation since the concept was first practically demonstrated ~40 years ago. Current technology is focusing on large, whole immunoglobulin formats (of which there are approaching 100 in clinical development), many with site-specifically conjugated payloads numbering 2 or 4. Despite the success of trastuzumab-emtansine in breast cancer, ADCs have generally failed to have an impact in solid tumours, leading many to explore alternative, smaller formats which have better penetrating properties as well as more rapid pharmacokinetics (PK). This review describes research and development progress over the last ~10 years obtained from the primary literature or conferences covering over a dozen different smaller for

SUBMITTER: Deonarain MP 

PROVIDER: S-EPMC6698822 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature