Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function.

ABSTRACT: Asymmetric bispecific antibodies are a rapidly expanding therapeutic antibody class, designed to recognize two different target epitopes concurrently to achieve novel functions not available with normal antibodies. Many therapeutic designs require antibodies with reduced or silenced effector function. Although many solutions have been described in the literature to knockout effector function, to date all of them have involved the use of a specific antibody subtype (e.g., IgG2 or IgG4), or symmetric mutations in the lower hinge or CH2 domain of traditional homodimeric monospecific antibodies. In the context of a heterodimeric Fc, we describe novel asymmetric Fc mutations with reduced or silenced effector function in this article. These heteromultimeric designs contain asymmetric charged mut

SUBMITTER: Escobar-Cabrera E 

PROVIDER: S-EPMC6698841 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature