A five-CpG signature of microRNA methylation in non-G-CIMP glioblastoma.

ABSTRACT:

Aims

DNA methylation has been found to regulate microRNAs (miRNAs) expression, but the prognostic value of miRNA-related DNA methylation aberration remained largely elusive in cancers including glioblastomas (GBMs). This study aimed to investigate the clinical and biological feature of miRNA methylation in GBMs of non-glioma-CpG island methylator phenotype (non-G-CIMP).

Methods

Prognostic miRNA methylation loci were analyzed, with TCGA and Rennes cohort as training sets, and independent datasets of GBMs and low-grade gliomas (LGGs) were obtained as validation sets. Different statistical and bioinformatic analysis and experimental validations were performed to clinically and biologically characterize the signature.

Results

We identified and validated a risk score based

SUBMITTER: Kang EM 

PROVIDER: S-EPMC6698977 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature