Molecular and clinical characterization of TMEM71 expression at the transcriptional level in glioma.

ABSTRACT:

Background

Glioma is the most common and aggressive type of primary brain tumor in adults. Although radiotherapy and chemotherapy are used in the treatment of glioma, survival remains unsatisfactory. Chemoresistance is one of the primary reasons for the poor prognosis of glioma. Several studies have demonstrated that glioma stem cells (GSC) may be one of the reasons for chemoresistance. In this article, we attempt to search for a new biomarker related to GSC and chemoresistance in glioma.

Methods

We used three datasets (GSE23806, COSMIC, and CGGA) to search for the genes related to GSC, temozolomide (TMZ) resistance, and overall survival. The selected gene was investigated with respect to the relationship between mRNA levels and clinical characteristics in the CGGA and TCGA

SUBMITTER: Wang KY 

PROVIDER: S-EPMC6698980 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature