A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping.

ABSTRACT: We discuss a decision-theoretic approach to building a panel-based, preemptive genotyping program. The method is based on findings that a large percentage of patients are prescribed medications that are known to have pharmacogenetic associations, and over time, a substantial proportion are prescribed additional such medication. Preemptive genotyping facilitates genotype-guided therapy at the time medications are prescribed; panel-based testing allows providers to reuse previously collected genetic data when a new indication arises. Because it is cost-prohibitive to conduct panel-based genotyping on all patients, we describe a three-step approach to identify patients with the highest anticipated benefit. First, we construct prediction models to estimate the risk of being prescribed one of t

SUBMITTER: Shi Y 

PROVIDER: S-EPMC6699004 | biostudies-literature | 2019 Jul-Dec

REPOSITORIES: biostudies-literature