Impact of Once- Versus Twice-Daily Tacrolimus Dosing on Medication Adherence in Stable Renal Transplant Recipients: A Canadian Single-Center Randomized Controlled Trial.

ABSTRACT:

Background

Prevalence of immunosuppressant nonadherence in renal transplant recipients is high despite negative clinical outcomes associated with nonadherence. Simplification of dosing has been demonstrated to improve adherence in renal transplant recipients as measured through electronic monitoring and self-report.

Objective

The purpose of this study was to replicate and extend previous findings by measuring adherence with multiple methods in a Canadian sample.

Design

The study design was a randomized controlled medication dosing trial in adult renal transplant patients. The trial length was 4 months.

Setting

This study was conducted within the Solid Organ Transplant (SOT) Clinic at Vancouver General Hospital (VGH; Vancouver, Canada).

Patients

A total o

SUBMITTER: Paterson TSE 

PROVIDER: S-EPMC6699008 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature