Intrinsically disordered domains: Sequence ➔ disorder ➔ function relationships.

ABSTRACT: Disordered domains are long regions of intrinsic disorder that ideally have conserved sequences, conserved disorder, and conserved functions. These domains were first noticed in protein-protein interactions that are distinct from the interactions between two structured domains and the interactions between structured domains and linear motifs or molecular recognition features (MoRFs). So far, disordered domains have not been systematically characterized. Here, we present a bioinformatics investigation of the sequence-disorder-function relationships for a set of probable disordered domains (PDDs) identified from the Pfam database. All the Pfam seed proteins from those domains with at least one PDD sequence were collected. Most often, if a set contains one PDD sequence, then all members of th

SUBMITTER: Zhou J 

PROVIDER: S-EPMC6699093 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature