Aberrant activity in conceptual networks underlies N400 deficits and unusual thoughts in schizophrenia.

ABSTRACT:

Background

The N400 event-related potential (ERP) is triggered by meaningful stimuli that are incongruous, or unmatched, with their semantic context. Functional magnetic resonance imaging (fMRI) studies have identified brain regions activated by semantic incongruity, but their precise links to the N400 ERP are unclear. In schizophrenia (SZ), N400 amplitude reduction is thought to reflect overly broad associations in semantic networks, but the abnormalities in brain networks underlying deficient N400 remain unknown. We utilized joint independent component analysis (JICA) to link temporal patterns in ERPs to neuroanatomical patterns from fMRI and investigate relationships between N400 amplitude and neuroanatomical activation in SZ patients and healthy controls (HC).

Methods

SZ

SUBMITTER: Jacob MS 

PROVIDER: S-EPMC6699247 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature